Ganglioside Antibodies GQ1b IgG OR IgM – Referral Test

Code:
GQ1B

Sample Type:

2mL Serum (Gel 5mL Yellow tube)

Ref Ranges/Units:

Negative or Positive

Normal result = Negative.

Turnaround:

3-4 weeks

Referred to Oxford University Hospital daily except Fridays

Special Precautions/Comments:

Interferences: None known

Additional Information:

Indication: Miller-Fisher Syndrome.

Background Information: IgG antibodies to ganglioside GQ1b are associated with Miller-Fisher syndrome and specifically those with opthalmoplegia. IgM antibodies to GQ1b are seen in some chronic ataxia neuropathies which share some common clinical features with the Miller-Fisher syndrome.

References: Rinaldi S, Willison HJ. Ganglioside antibodies and neuropathies. Current Opinion in Neurology. 2008. 21(5): 540-546. Willison HJ, Plomp JJ. Anti-ganglioside antibodies and the pre-synaptic motor nerve terminal. Ann NY Acad Sci. 2008. 1132:114-23. Lo YL. Clinical and immunological spectrum of the miller fisher syndrome. Muscle and Nerve. 2007. 36(5):615-627. Chaudhry F, Gee KE, Vaphiades MS. GQ1b antibody testing in Guillain-Barre syndrome and variants. Seminars in Opthalmology. 2006. 21(4):223-227

See Also: GM1 (IgG/IgM)

Telephone Gateshead Lab: 0191.4456499 Option 4, Option 1

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