Phenobarbitone (phenobarbital)

Special Precautions/Comments:

Trough sample recommended (blood drawn immediately before scheduled dose). If not possible, ensure sample is always taken at same time for monitoring. 

Additional Information:

Phenobarbital is a commonly used barbiturate which is effective as an anti-convulsant in the treatment of all types of seizures except absence seizures. 

High doses of phenobarbital (>40 mg/L) are associated with toxicity. Therapeutic drug monitoring allows the optimal therapeutic dose to be achieved by avoiding both subtherapeutic and toxic levels.